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GNE7915, LRRK2 inhibitor (ab270803)

Key features and details

  • Potent and selective, brain penetrant LRRK2 inhibitor.
  • CAS Number: 1351761-44-8
  • Purity: > 99%

  • Soluble in DMSO to 50 mM warming

  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    GNE7915, LRRK2 inhibitor

  • Description

    Potent and selective, brain penetrant LRRK2 inhibitor.

  • Biological description

    Potent and selective, brain penetrant LRRK2 inhibitor (IC50 = 9 nM; Ki = 1nM). Tested against a panel of 187 kinases only one was inhibited >50% at 100 nM. Displays moderate 5-HT2B anatagonist activity in vitro.

  • Purity

    > 99%

  • CAS Number

    1351761-44-8

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-methanone

  • Molecular weight

    443.40

  • Molecular formula

    C19H21F4N5O3

  • PubChem identifier

    58539171

  • Storage instructions

    Shipped at room temperature. Store at -20°C.

  • Solubility overview

    Soluble in DMSO to 50 mM warming

  • Handling

    Toxic, refer to SDS for further information

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC

  • Source

    Synthetic

Images

  • Chemical Structure - GNE7915, LRRK2 inhibitor (ab270803)
    Chemical Structure - GNE7915, LRRK2 inhibitor (ab270803)

    Chemical structure of GNE7915, LRRK2 inhibitor, 1351761-44-8

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