DBeQ, p97 ATPase inhibitor (ab141254)
Key features and details
- Selective, potent, reversible and ATP competitive p97 ATPase inhibitor
- CAS Number: 177355-84-9
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 20 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
DBeQ, p97 ATPase inhibitor -
Description
Selective, potent, reversible and ATP competitive p97 ATPase inhibitor -
Alternative names
- N2,N4-dibenzylquinazoline-2,4-diamine
-
Biological description
Selective, potent, reversible and ATP-competitive p97 ATPase inhibitor (IC50 = 1.5 μM). Inhibits a number of cellular processes including ER-associated degradation, ubiquitin fusion degradation and autophagosome maturation. Decreases cancer cell growth and induces activation of caspases 3 and 7.
-
Purity
> 99% -
CAS Number
177355-84-9 -
Chemical structure
Properties
-
Chemical name
N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine -
Molecular weight
340.42 -
Molecular formula
C22H20N4 -
PubChem identifier
676352 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 20 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
c3cccc4nc(NCc1ccccc1)nc(NCc2ccccc2)c34 -
Source
Synthetic
-
Research areas
