BMH 21, RNA polymerase I inhibitor (ab219384)
Key features and details
- RNA polymerase I inhibitor
- CAS Number: 896705-16-1
- Purity: > 99%
- Soluble in DMSO to 5 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BMH 21, RNA polymerase I inhibitor -
Description
RNA polymerase I inhibitor -
Alternative names
- BMH-21
- BMH21
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Biological description
Potent, small molecule DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. Causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. Also acts as a p53 pathway activator; induces expression of p53 target genes. Antitumorigenic activity against a broad range of cancer cell lines and represses tumor growth in vivo.
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Purity
> 99% -
CAS Number
896705-16-1 -
Chemical structure
Properties
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Chemical name
N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide -
Molecular weight
360.41 -
Molecular formula
C21H20N4O2 -
PubChem identifier
3508054 -
Storage instructions
Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 5 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CCNC(=O)C1=CC=CN2C1=NC3=CC4=CC=CC=C4C=C3C2=O -
Source
Synthetic
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Research areas
