Bisindolylmaleimide IV, PKC inhibitor (ab144208)
Key features and details
- Potent cell-permeable PKC inhibitor
- CAS Number: 119139-23-0
- Purity: > 98%
- Soluble ethanol to 50 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Bisindolylmaleimide IV, PKC inhibitor -
Description
Potent cell-permeable PKC inhibitor -
Biological description
Potent cell-permeable PKC inhibitor (IC50 values are 0.1 - 0.55 μM). Inhibits PKA (IC50 values are 2 - 11.8 µM). Noncompetitive nAChR antagonist. Shows less potent antinicotinic effects than Bisindolylmaleimide II (ab144206). Induces apoptosis and shows antiproliferative effects. -
Purity
> 98% -
CAS Number
119139-23-0 -
Chemical structure
Properties
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Chemical name
2,3-Bis(1H-indol-3-yl)maleimide -
Molecular weight
327.34 -
Molecular formula
C20H13N3O2 -
PubChem identifier
2399 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble ethanol to 50 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54 -
Source
Synthetic
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Research areas
