Astana Biomed Group, an authorized Abcam distributor in Central Asia

Galanthamine, cholinesterase inhibitor (ab269700)

Key features and details

  • Potent selective acetylcholinesterase inhibitor.
  • CAS Number: 357-70-0
  • Soluble in DMSO to 50 mM and in ethanol to 100 mM with gentle warming
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Galanthamine, cholinesterase inhibitor

  • Description

    Potent selective acetylcholinesterase inhibitor.

  • Biological description

    Potent selective acetylcholinesterase inhibitor (IC50 = 410 nM). Greater than 50-fold selective versus butyrylcholinesterase. Inhibits RBC cholinesterase activity 10-fold more potently than that of human brain tissue. Reduces apoptotic effect of thapsigargin in SH-SY5Y cells. Non-competitive nicotinic receptor aganist in rat PC12 cells. Neuroprotective following ischemia-reperfusion injury in animal models.

  • CAS Number

    357-70-0

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol

  • Molecular weight

    287.35

  • Molecular formula

    C17H21NO3

  • PubChem identifier

    9651

  • Storage instructions

    Shipped at room temperature. Store at -20°C.

  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 100 mM with gentle warming

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O

  • Source

    Synthetic

Images

  • Chemical Structure - Galanthamine, cholinesterase inhibitor (ab269700)
    Chemical Structure - Galanthamine, cholinesterase inhibitor (ab269700)

    Chemical structure of Galanthamine, cholinesterase inhibitor, 357-70-0

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

© 2021 Astana Biomed Group LLP. All rights reserved.