BIO-acetoxime, GSK-3alpha/beta inhibitor (ab142811)
Key features and details
- Potent and selective GSK-3α/β inhibitor
- CAS Number: 667463-85-6
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BIO-acetoxime, GSK-3alpha/beta inhibitor -
Description
Potent and selective GSK-3α/β inhibitor -
Biological description
Potent and selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling. Inhibits CD8+ T cell differentiation. Shows antiapoptotic effects.
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Purity
> 98% -
CAS Number
667463-85-6 -
Chemical structure
Properties
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Chemical name
3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-indol-2-one -
Molecular weight
398.22 -
Molecular formula
C18H12BrN3O3 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)O\N=C3/c4ccccc4N/C3=C1/c2ccc(Br)cc2NC1=O -
Source
Synthetic
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Research areas
