Asenapine maleate, 5-HT receptor antagonist and D2 antagonist (ab120576)
Key features and details
- Multiple receptor antagonist. Antipsychotic agent.
- CAS Number: 85650-56-2
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Asenapine maleate, 5-HT receptor antagonist and D2 antagonist -
Description
Multiple receptor antagonist. Antipsychotic agent. -
Alternative names
- ASE
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Biological description
Novel, multiple receptor antagonist. Displays activity at 5-HT, dopamine, adrenoceptors and histamine receptors. (pKi values are 8.60 (5-HT1A), 8.40 (5-HT1B), 10.15 (5-HT2A), 9.75 (5-HT2B), 10.46 (5-HT2C), 8.84 (5-HT5A), 9.60 (5-HT6), 9.94 (5-HT7), 8.85 (D1), 8.90 (D2L), 8.84 (D2S), 9.38 (D3), 8.95 (D4), 8.93 (α1A), 8.9 (α2A), 9.49 (α2B), 8.91 (α2C), 9.00 (H1) and 8.21(H2)). Increases dopamine, norepinephrine and acetylcholine efflux. Antipsychotic in vivo.
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Purity
> 99% -
CAS Number
85650-56-2 -
Chemical structure
Properties
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Chemical name
trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole maleate -
Molecular weight
401.85 -
Molecular formula
C17H16ClNO.C4H4O4 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
