Anti-SLAM / CD150 antibody [IPO-3] (ab2604)
Key features and details
- Mouse monoclonal [IPO-3] to SLAM / CD150
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-SLAM / CD150 antibody [IPO-3]
See all SLAM / CD150 primary antibodies -
Description
Mouse monoclonal [IPO-3] to SLAM / CD150 -
Host species
Mouse -
Specificity
This antibody is specific for SLAM. -
Species reactivity
Reacts with: Human -
Immunogen
Activated B cell line
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Epitope
The exact epitope recognised by this antibody has not been mapped. -
General notes
A novel glycoprotein of 70kDa, designated SLAM (Signaling Lymphocyte Activation Molecule) / CDw150, that belongs to the immunoglobulin gene superfamily and is involved in T-cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane-bound form of SLAM and the soluble and cytoplasmic isoforms of SLAM, and that the expression levels of membrane-bound SLAM on B cells are rapidly regulated after activation in vitro. It is suggested that signaling through homophilic SLAM-SLAM binding during B-B and B-T cell interactions enhances the expansion and differentiation of activated B cells.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.01% Sodium azide -
Concentration information loading... -
Purity
Protein A purified -
Primary antibody notes
A novel glycoprotein of 70kDa, designated SLAM (Signaling Lymphocyte Activation Molecule) / CDw150, that belongs to the immunoglobulin gene superfamily and is involved in T-cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane-bound form of SLAM and the soluble and cytoplasmic isoforms of SLAM, and that the expression levels of membrane-bound SLAM on B cells are rapidly regulated after activation in vitro. It is suggested that signaling through homophilic SLAM-SLAM binding during B-B and B-T cell interactions enhances the expansion and differentiation of activated B cells. -
Clonality
Monoclonal -
Clone number
IPO-3 -
Myeloma
unknown -
Isotype
IgG1 -
Light chain type
unknown -
Research areas
