5-Azacytidine, DNMT1 inhibitor (ab142744)
Key features and details
- Potent DNMT1 inhibitor. Induces DNA hypomethylation.
- CAS Number: 320-67-2
- Purity: > 98%
- Soluble in water to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
5-Azacytidine, DNMT1 inhibitor -
Description
Potent DNMT1 inhibitor. Induces DNA hypomethylation. -
Alternative names
- 5-AzadCyD
- Dacogen
- NSC 102816
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Biological description
Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows anti-metabolic and anti-cancer activities in vitro. Active in vivo. At high doses the compound can have effects on other DNA methyltransferases.
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Purity
> 98% -
CAS Number
320-67-2 -
Chemical structure
