Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor (ab144494)
Key features and details
- Selective Rho kinase inhibitor. 1 ml water soluble pack.
- CAS Number: 129830-38-2
- Purity: > 99%
- Soluble in 1 of ml water to give specified mM/ml concentration
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor -
Description
Selective Rho kinase inhibitor. 1 ml water soluble pack. -
Biological description
Selective Rho kinase inhibitor.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more. -
Purity
> 99% -
CAS Number
129830-38-2 -
Chemical structure
Properties
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Chemical name
(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride -
Molecular weight
320.26 -
Molecular formula
C14H21N3O.2HCl -
PubChem identifier
9901617 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1 of ml water to give specified mM/ml concentration -
Handling
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.O=C(Nc1ccncc1)[C@@H]2CC[C@H](CC2)[C@@H](C)N -
Source
Synthetic
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Research areas
Images
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Functional Studies - Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor (ab144494) Takazawa et al PLoS One. 2012;7(7):e40154. doi: 10.1371/journal.pone.0040154. Epub 2012 Jul 3. Fig 2. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
Representative morphology and membrane potential responses to current step injection in hESMNs at 3 different times in vitro.
Imaging of cells fixed after patch-clamp recordings indicate that recorded cells express the Hb9::GFP reporter transgene (A-C,E,G,and I). Voltage responses and imaging in the same rows are taken from same neurons. The neurons for A-C are same as that shown in F and G. D,F,H show examples of voltage responses to current steps recorded from 3 neurons current-clamped at −58 mV, −60 mV, and −55 mV, respectively. Bottom traces in D,F, and H show injected currents. Scale bars in images are 50 μm.
Only part of full image panel shown.
Cells were pre-treated with ab144494.
