Xestospongin C, IP3 receptor antagonist (ab120914)
Key features and details
- Potent, selective, reversible IP3 receptor antagonist
- CAS Number: 88903-69-9
- Purity: > 90%
- Soluble in DMSO to 2 mM and in ethanol to 2 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Xestospongin C, IP3 receptor antagonist -
Description
Potent, selective, reversible IP3 receptor antagonist -
Alternative names
- Araguspongine E
- XeC
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Biological description
Potent, selective, reversible IP3 receptor antagonist (IC50 = 350 nM). Inhibits IP3-mediated Ca2+ release from ER and SR. 30-Fold selectivity over ryanodine receptor. Inhibits voltage-dependent Ca2+ and K+ channels at higher concentrations. Cell-permeable. -
Purity
> 90% -
CAS Number
88903-69-9 -
Chemical structure
Properties
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Chemical name
(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine -
Molecular weight
446.72 -
Molecular formula
C28H50N2O2 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 2 mM and in ethanol to 2 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CCC[C@H]2CCCN3CCC(CCCCCCC4CCCN5CCC(CC1)O[C@H]45)O[C@H]23 -
Source
Synthetic
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Research areas
