L-685,458, gamma-secretase inhibitor (ab141414)
Key features and details
- Potent, selective and non-competitive γ-secretase inhibitor
- CAS Number: 292632-98-5
- Purity: > 98%
- Supplied in DMSO (1 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
L-685,458, gamma-secretase inhibitor -
Description
Potent, selective and non-competitive γ-secretase inhibitor -
Alternative names
- (5S)-(t-Butoxycarbonylamino)-6-phenyl-(4R)hydroxy-(2R)benzylhexanoyl)-L-leu-L-phe-amide
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Biological description
Potent, selective and non-competitive γ-secretase inhibitor (IC50 = 17 nM). Shows 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Inhibits Aβ40 and Aβ42 peptides (IC50 values are 48 and 67 nM respectively). Active in vivo. Orally active.
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Purity
> 98% -
CAS Number
292632-98-5 -
Chemical structure
Properties
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Chemical name
(5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide -
Molecular weight
672.85 -
Molecular formula
C39H52N4O6 -
PubChem identifier
456313 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Supplied in DMSO (1 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)C(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O -
Source
Synthetic
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Research areas