WIKI4, Wnt/ beta catenin inhibitor (ab147053)
Key features and details
- Potent Wnt/ beta catenin inhibitor
- CAS Number: 838818-26-1
- Purity: > 98%
- Soluble in DMSO to 20 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
WIKI4, Wnt/ beta catenin inhibitor -
Description
Potent Wnt/ beta catenin inhibitor -
Alternative names
- Tankyrase 1/2 Inhibitor V
- WIKI-4
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Biological description
WIKI-4 is a potent inhibitor of Wnt/β-catenin signaling EC50 ~ 75 nM (in all cell lines tested including DLD1 colorectal cancer cells, NALM6 B cells, U-2 OS osteosarcoma cells, and hESCs); inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM). Also a potent and selective inhibitor of TNKS1 and TNKS2 (IC50s = 26 and 15 nM, respectively). It has little or no effect on related polymerases or transferases at 10 µM. Through its effects on TNKS2, WIKI4 prevents AXIN ubiquitinylation and degradation, blocking signaling through the Wnt/β-
catenin pathway. WIKI4 inhibits the expression of β- catenin target genes and cellular responses to Wnt/β- catenin signaling in both cancer cell lines and embryonic stem cells -
Purity
> 98% -
General notes
Protect from air and light.
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CAS Number
838818-26-1
Properties
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Chemical name
1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one -
Molecular weight
521.59 -
Molecular formula
C29H23N5O3S -
PubChem identifier
2984337 -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 20 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC=C(C=C1)N2C(=NN=C2SCCCN3C(=O)C4=CC=CC5=C4C(=CC=C5)C3=O)C6=CC=NC=C6 -
Source
Synthetic
