SecinH3, Sec7-GEF inhibitor (ab145048)
Key features and details
- Selective Sec7-GEF inhibitor
- CAS Number: 853625-60-2
- Purity: > 99%
- Soluble in ethanol to 10 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SecinH3, Sec7-GEF inhibitor -
Description
Selective Sec7-GEF inhibitor -
Biological description
Selective Sec7-GEF inhibitor (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, Drosophila steppke, yGea2-S7 and hEFA6-S7, respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein phosphorylation. Cell-permeable.
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Purity
> 99% -
CAS Number
853625-60-2 -
Chemical structure
Properties
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Chemical name
N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide -
Molecular weight
460.51 -
Molecular formula
C24H20N4O4S -
PubChem identifier
1029232 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 10 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(CSc1ccccc1)Nc2ccc(cc2)n5nc(OC)nc5c3ccc4OCOc4c3 -
Source
Synthetic
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Research areas
