SC-514, IKKbeta inhibitor (ab144415)
Key features and details
- Selective, ATP-competitive, irreversible IKKβ inhibitor
- CAS Number: 354812-17-2
- Purity: > 98%
- Soluble in ethanol to 10 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SC-514, IKKbeta inhibitor -
Description
Selective, ATP-competitive, irreversible IKKβ inhibitor -
Biological description
Selective, ATP-competitive, irreversible IKKβ inhibitor (IC50 = 3-12 μM). Reduces iNOS induction. Shows anti-inflammatory effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
354812-17-2 -
Chemical structure
Properties
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Chemical name
3-Amino-5-thiophen-3-ylthiophene-2-carboxamide -
Molecular weight
224.30 -
Molecular formula
C9H8N2OS2 -
PubChem identifier
2807869 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 10 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CSC=C1C2=CC(=C(S2)C(=O)N)N -
Source
Synthetic
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Research areas