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Neuroscience Neurology process Neurodegenerative disease Alzheimer's disease Tangles & Tau

Chaetoglobosin A, Antibiotic agent (ab144219)

Key features and details

  • Antibiotic agent. Phytotoxin.
  • CAS Number: 50335-03-0
  • Purity: > 98%
  • Soluble in DMSO to 10 mM
  • Form / State: Solid
  • Source: Chaetomium sp.

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Overview

  • Product name

    Chaetoglobosin A, Antibiotic agent
  • Description

    Antibiotic agent. Phytotoxin.
  • Biological description

    Antibiotic agent. Phytotoxin. Cytochalasin analog (ab143481, ab143482, ab143483, ab143484, ab141788). Targets filamentous actin and induces apoptosis. Shows cytotoxic effects against cancer cell lines. Shows antibacterial and nematicidal effects. Induces tissue necrosis in vivo.
  • Purity

    > 98%
  • CAS Number

    50335-03-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (7S,13E,16S,17E,19R,21E)-6,7-Epoxy-19-hydroxy-10-(1H-indol-3-yl)-16,18-dimethyl- [13]cytochalasa-13,17,21-triene-1,20,23-trione
  • Molecular weight

    528.64
  • Molecular formula

    C32H36N2O5
  • PubChem identifier

    6438437
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@H]\1C/C=C/[C@H]2[C@H]3[C@](O3)([C@H]([C@@H]4[C@@]2(C(=O)/C=C/C(=O)[C@@H](/C(=C1)/C)O)C(=O)N[C@H]4CC5=CNC6=CC=CC=C65)C)C
  • Source

    Chaetomium sp.

  • Research areas

    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Alzheimer's disease
    • Tangles & Tau
    • Cardiovascular
    • Blood
    • Fibrinolysis / Thrombolysis
    • Immunology
    • Cell Type Markers
    • CD
    • Myeloid Cells
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cytoskeleton
    • Microtubules
    • MT Associated Proteins
    • Tau
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Synthesis
    • Topoisomerases
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Synthesis
    • Other
    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Other
    • Neuroscience
    • Cell Type Marker
    • Neuron marker
    • Axon marker
    • Cancer
    • Cell cycle
    • Cell division
    • Cancer
    • Invasion/microenvironment
    • Angiogenesis
    • Angiogenic inhibitory factors
    • Cancer
    • Invasion/microenvironment
    • ECM
    • Extracellular matrix
    • Other
    • Cell Biology
    • Proteolysis / Ubiquitin
    • Proteolytic enzymes
    • Other proteases
    • Cancer
    • Tumor biomarkers
    • Receptors
    • Biochemicals
    • Product Range
    • New
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Chemical Type
    • Toxin
    • Biochemicals
    • Chemical Type
    • Antibiotic
    • Biochemicals
    • Pharmacology
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Pharmacology
    • Signaling
    • Cytoskeleton & motor proteins
    • Actin

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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