SB 202190, cell-permeable p38 MAPK inhibitor (ab120638)
Key features and details
- Highly selective, potent, cell-permeable p38 MAPK inhibitor
- CAS Number: 152121-30-7
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
SB 202190, cell-permeable p38 MAPK inhibitor -
Description
Highly selective, potent, cell-permeable p38 MAPK inhibitor -
Purity
> 99% -
CAS Number
152121-30-7 -
Chemical structure
Properties
-
Chemical name
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole -
Molecular weight
331.35 -
Molecular formula
C20H14FN3O -
PubChem identifier
5169 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O -
Source
Synthetic
-
Research areas
Images
-
Functional Studies - SB 202190, cell-permeable p38 MAPK inhibitor (ab120638)ab18528 staining Lamp2a in CaCO2 cells treated with SB 202190 (ab120638), by ICC/IF. Increase of Lamp2a expression correlates with increased concentration of SB 202190, as described in literature.
The cells were incubated at 37°C for 3 hours in media containing different concentrations of ab120638 (SB 202190) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18528 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
