Ryanodine, Ca2+ release modulator (ab120083)
Key features and details
- Ca2+ release modulator
- CAS Number: 15662-33-6
- Purity: > 98%
- Soluble in ethanol to 10 mM
- Form / State: Solid
- Source: Ryania speciosa
Overview
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Product name
Ryanodine, Ca2+ release modulator -
Description
Ca2+ release modulator -
Biological description
Alkaloid that binds with high affinity to ryanodine receptors to modulate intracellular Ca2+ release. Has complex actions and may stimulate or inhibit Ca2+ release, depending on the concentration used.
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Purity
> 98% -
CAS Number
15662-33-6 -
Chemical structure
Properties
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Chemical name
1H-Pyrrole-2-carboxylic acid (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2] pentaleno[1,6-bc]furan-8-yl ester -
Molecular weight
493.55 -
Molecular formula
C25H35NO9 -
PubChem identifier
5114 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)[C@@]6(O)C(OC(=O)c1cccn1)[C@]2(O)[C@@]5(O)[C@@]34O[C@@](O)(C[C@@]2(C)[C@@]4(O)CC[C@H](C)[C@H]3O)[C@]56C -
Source
Ryania speciosa
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Research areas
Images
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Functional Studies - Ryanodine, Ca2+ release modulator (ab120083) Image from Touchberry CD et al., J Biol Chem. 2010;285(51):40312-21. Fig 4(A-B).; doi: 10.1074/jbc.M110.179689.Ryanodine inhibits the elevation of intracellular Ca2+ by PI(3,5)P2 in primary cardiac myocytes. Top figure shows fura-2 ratiometric changes in intracellular Ca2+ in an isolated ventricular adult cardiac myocyte after treatment with PI(3,5)P2, ultimately resulting in contraction. Bottom figure shows that ryanodine inhibited the release of SR Ca2+ to both caffeine and PI(3,5)P2.