(R,S)-3,5-DHPG, group I mGlu receptor agonist (ab120020)
Key features and details
- Group I mGlu receptor agonist
- CAS Number: 19641-83-9
- Purity: > 98%
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(R,S)-3,5-DHPG, group I mGlu receptor agonist -
Description
Group I mGlu receptor agonist -
Biological description
Selective group I mGlu receptor agonist
Also available in simple stock solutions (ab146669) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 98% -
CAS Number
19641-83-9 -
Chemical structure
Properties
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Chemical name
(R,S)-3,5-Dihydroxyphenylglycine -
Molecular weight
183.16 -
Molecular formula
C8H9NO4 -
PubChem identifier
108001 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in water to 10 mM -
Handling
This compound is also unstable in alkaline solution when it rapidly forms a brown colouration it is therefore recommended that alkaline is not used to dissolve this compound.
We recommend stock solutions are made up in water, aliquoted immediately and stored at -20°C. They should be used within one week.Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Oc1cc(cc(O)c1)C(N)C(=O)O -
Source
Synthetic
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Research areas
Images
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Functional Studies - (R,S)-3,5-DHPG, group I mGlu receptor agonist (ab120020)ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-3,5-DHPG (ab120020), by ICC/IF. Increase in FMRP expression correlates with increased concentration of (R,S)-3,5-DHPG, as described in literature.
The cells were incubated at 37°C for 1h in media containing different concentrations of ab120020 ((R,S)-3,5-DHPG) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
