Fenobam, mGlu5 antagonist (ab120034)
Key features and details
- Selective, potent, orally active mGlu5 antagonist
- CAS Number: 57653-26-6
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Fenobam, mGlu5 antagonist -
Description
Selective, potent, orally active mGlu5 antagonist -
Biological description
Selective, potent mGlu5 receptor antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM at rat and human recombinant mGlu5 receptors, respectively). Displays inverse agonist properties and blocks mGlu5 receptor basal activity (IC50 = 84 nM). Orally active, atypical anxiolytic.
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Purity
> 99% -
CAS Number
57653-26-6 -
Chemical structure
Properties
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Chemical name
1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea -
Molecular weight
266.68 -
Molecular formula
C11H11ClN4O2 -
PubChem identifier
162834 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C2N=C(NC(=O)Nc1cccc(Cl)c1)N(C)C2 -
Source
Synthetic
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Research areas
