Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064)
Key features and details
- Endogenous ionotropic / nicotinic antagonist
- CAS Number: 492-27-3
- Purity: > 99%
- Soluble in 1 eq. NaOH to 100 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Kynurenic acid, endogenous ionotropic / nicotinic antagonist -
Description
Endogenous ionotropic / nicotinic antagonist -
Biological description
Endogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective in vivo. Water-soluble form available - please see Kynurenic acid sodium salt (ab120256)
-
Purity
> 99% -
CAS Number
492-27-3 -
Chemical structure
Properties
-
Chemical name
4-Hydroxyquinoline-2-carboxylic acid -
Molecular weight
189.17 -
Molecular formula
C10H7NO3 -
PubChem identifier
3845 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1 eq. NaOH to 100 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
O=C(O)c1cc(O)c2ccccc2n1 -
Source
Synthetic
-
Research areas
Images
-
Functional Studies - Kynurenic acid, endogenous ionotropic / nicotinic antagonist (ab120064) Image from Rudolph S et al., Neuron. 2011;70(5):991-1004. Fig 3.; doi: 10.1016/j.neuron.2011.03.029 with permission from Elsevier.C1 and C2 - Inhibition of climbing fiber to Purkinje cell EPSCs in (control; black) by 1 mM Kynurenic acid (red, ab120064) or 100 nM NBQX (green, ab120045) recorded in 2.5 mM external Ca2+ at 0.05 Hz (C1) and 2 Hz (C2) stimulation frequency. D - Summary of inhibition of EPSCs by 1 mM Kynurenic acid (red, ab120064) and 100 nM NBQX (green, ab120045) in 2.5 mM external Ca2+.
