LY 379268, Group II mGlu agonist (ab120196)
Key features and details
- Group II mGlu agonist. Systemically active.
- CAS Number: 191471-52-0
- Purity: > 99%
- Soluble in water to 25 mM (with heating)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
LY 379268, Group II mGlu agonist -
Description
Group II mGlu agonist. Systemically active. -
Biological description
Highly potent and systemically active mGlu2 and mGlu3 agonist. EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively and displays >80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain.
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Purity
> 99% -
CAS Number
191471-52-0 -
Chemical structure
Properties
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Chemical name
(1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid -
Molecular weight
187.15 -
Molecular formula
C7H9NO5 -
PubChem identifier
10197984 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25 mM (with heating) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OC(=O)[C@]2(N)CO[C@H]1[C@H](C(=O)O)[C@H]12 -
Source
Synthetic
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Research areas
