(R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist (ab120252)
Key features and details
- Group I /II metabotropic glutamate antagonist; water soluble
- CAS Number: 1303994-09-3
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist -
Description
Group I /II metabotropic glutamate antagonist; water soluble -
Biological description
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Purity
> 99% -
CAS Number
1303994-09-3 -
Chemical structure
Properties
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Chemical name
(R,S)-α-Methyl-4-carboxyphenylglycine sodium salt -
Molecular weight
231.18 -
Molecular formula
C10H10NNaO4 -
PubChem identifier
133698095 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C1=CC=C(C=C1)C(=O)O)(C(=O)[O-])N.[Na+] -
Source
Synthetic
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Research areas
Images
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Functional Studies - (R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist (ab120252)ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-MCPG sodium salt (ab120252), by ICC/IF. Decrease of FMRP expression correlates with increased concentration of (R,S)-MCPG sodium salt, as described in literature.
The cells were incubated at 37°C for 2h in media containing different concentrations of ab120252 ((R,S)-MCPG sodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
