Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Mouse PEDF protein (ab185860)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Suitable for: SDS-PAGE, HPLC

Description

  • Product name

    Recombinant Mouse PEDF protein
    See all PEDF proteins and peptides

  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Accession

    P97298

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Mouse

    • Sequence

      MDPFFKVPVNKLAAAVSNFGYDLYRLRSSASPTGNVLLSPLSVATALSAL SLGAEHRTESVIHRA LYYDLITNPDIHSTYKELLASVTAPEKNLKSASRIVFERKLRVKSSFVAP LEKSYGTRPRILTGN PRVDLQEINNWVQAQMKGKIARSTREMPSALSILLLGVAYFKGQWVTKFD SRKTTLQDFHLDEDR TVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGSMSIIFFLPLTVTQNLT MIEESLTSEFIHDID RELKTIQAVLTVPKLKLSFEGELTKSLQDMKLQSLFESPDFSKITGKPVK LTQVEHRAAFEWNEE GAGSSPSPGLQPVRLTFPLDYHLNQPFLFVLRDTDTGALLFIGRILDPSS T

    • Predicted molecular weight

      46 kDa

    • Amino acids

      43 to 417

    • Specifications

    Our Abpromise guarantee covers the use of ab185860 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      HPLC

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 7.40
      Constituent: 100% PBS

    General Info

    • Alternative names

      • Cell proliferation-inducing gene 35 protein
      • EPC 1
      • EPC-1
      • EPC1
      • OI12
      • OI6
      • PEDF
      • PEDF_HUMAN
      • PIG 35
      • PIG35
      • Pigment epithelium derived factor
      • Pigment epithelium-derived factor
      • Proliferation inducing protein 35
      • Serine (or cysteine) proteinase inhibitor
      • serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
      • Serpin F1
      • Serpin family F member 1
      • Serpin peptidase inhibitor
      • Serpin peptidase inhibitor clade F member 1
      • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
      • SERPINF 1
      • Serpinf1
      see all

    • Function

      Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

    • Tissue specificity

      Retinal pigment epithelial cells and blood plasma.

    • Sequence similarities

      Belongs to the serpin family.

    • Developmental stage

      Expressed in quiescent cells.

    • Domain

      The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.

    • Post-translational
      modifications

      The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.
      N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

    • Cellular localization

      Secreted. Melanosome. Enriched in stage I melanosomes.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab185860? Please let us know so that we can cite the reference in this datasheet.

ab185860 has not yet been referenced specifically in any publications.

Preparation and Storage

  • Cell proliferation-inducing gene 35 protein
  • EPC 1
  • EPC-1

Images

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