Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Mouse CD86 protein (His tag) (ab215653)

Key features and details

  • Expression system: Mammalian
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag C-Terminus
  • Suitable for: SDS-PAGE

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C long term.

    pH: 7.40
    Constituent: 100% PBS

    Lyophilized from a 0.2 µm filtered solution

  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Reconstitute with ddH2O to a concentration no less than 100 µg/mL. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at

    General Info

    • Alternative names

      • Activation B7-2 antigen
      • Activation B7-2 antigen 3
      • B-lymphocyte activation antigen B7-2
      • B-lymphocyte activation antigen B7-2 2
      • B7
      • B7 2
      • B7-2
      • B7.2
      • B70
      • B72
      • B72 antigen
      • BU63
      • CD28 antigen ligand 2
      • CD28 antigen ligand 2 2
      • Cd28l2
      • CD28LG2
      • CD86
      • CD86 antigen
      • CD86 antigen (CD28 antigen ligand 2 B7 2 antigen)
      • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
      • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 1, 2
      • CD86 molecule
      • CD86_HUMAN
      • CLS1
      • CTLA-4 counter-receptor B7.2
      • CTLA-4 counter-receptor B7.2 2
      • CTLA-4 counter-receptor B7.2 2, 3
      • Early T-cell costimulatory molecule 1
      • ETC-1
      • FUN 1
      • FUN-1
      • FUN1
      • LAB72
      • Ly-58
      • Ly58
      • MB7
      • MB7-2
      • Membrane glycoprotein
      • MGC34413
      • T lymphocyte activation antigen CD86 precursor
      • T-lymphocyte activation antigen CD86
      • TS/A-2
      see all

    • Function

      Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

    • Tissue specificity

      Expressed by activated B-lymphocytes and monocytes.

    • Sequence similarities

      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Post-translational
      modifications

      Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.

    • Cellular localization

      Membrane.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Mouse CD86 protein (His tag) (ab215653)
      SDS-PAGE - Recombinant Mouse CD86 protein (His tag) (ab215653)

      SDS Page analysis of ab215653: Lane 1: reducing conditions; Lane 2: non reducing conditions.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

References (0)

Publishing research using ab215653? Please let us know so that we can cite the reference in this datasheet.

ab215653 has not yet been referenced specifically in any publications.

Images

  • SDS-PAGE - Recombinant Mouse CD86 protein (His tag) (ab215653)
    SDS-PAGE - Recombinant Mouse CD86 protein (His tag) (ab215653)

    SDS Page analysis of ab215653: Lane 1: reducing conditions; Lane 2: non reducing conditions.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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