Recombinant human VEGF Receptor 3 protein (Active) (ab219663)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
Preparation and Storage
-
Alternative names
- EC 2.7.10.1
- flt 4
- FLT-4
see all -
Function
Receptor for VEGFC. Has a tyrosine-protein kinase activity. -
Tissue specificity
Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain. -
Involvement in disease
Defects in FLT4 are the cause of lymphedema hereditary type 1A (LMPH1A) [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.
Note=Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue. -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
Cellular localization
Membrane. - Information by UniProt
Images
-
SDS-PAGE - Recombinant human VEGF Receptor 3 protein (Active) (ab219663)
ab219663 on SDS-PAGE under reducing (R) and non-reducing (NR) conditions.
The gel was stained overnight with Coomassie Blue.
The purity of the protein is greater than 95%.
The protein has a calculated MW of 111.2 kDa. As a result of glycosylation, the protein migrates as 140-160 kDa under reducing (R) conditions and 280-320 kDa under non-reducing (NR) conditions.
-
Functional Studies - Recombinant human VEGF Receptor 3 protein (Active) (ab219663)Immobilized Human VEGF-C, His Tag at 5 μg/mL (100 μL/well) can bind ab219663 with a linear range of 0.6-10 ng/mL.
-
Functional Studies - Recombinant human VEGF Receptor 3 protein (Active) (ab219663)Immobilized ab219663 at 5 μg/mL (100 μL/well) can bind Human VEGF-D, His Tag, Strep Tag with a linear range of 0.08-0.6 μg/mL.
