Recombinant human VEGF Receptor 3 protein (ab95247)
Key features and details
- Expression system: Baculovirus
- Purity: > 70% SDS-PAGE
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
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Product name
Recombinant human VEGF Receptor 3 protein
See all VEGF Receptor 3 proteins and peptides -
Biological activity
Specific Activity: 17 pmol/min/µg. Assay conditions: VEGFR3 was incubated with a substrate (Tyr peptide 4 for 1h at RT in 1Xkinase buffer supplemented with ATP. Developer solution was added to reaction and reaction was stopped after 1h of incubation at RT. -
Purity
> 70 % SDS-PAGE.
ab95247 is >70% pure as assessed by SDS PAGE. -
Expression system
Baculovirus -
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Amino acids
798 to 1298
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Preparation and Storage
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Alternative names
- EC 2.7.10.1
- flt 4
- FLT-4
see all -
Function
Receptor for VEGFC. Has a tyrosine-protein kinase activity. -
Tissue specificity
Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain. -
Involvement in disease
Defects in FLT4 are the cause of lymphedema hereditary type 1A (LMPH1A) [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.
Note=Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue. -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
Cellular localization
Membrane. - Information by UniProt
Images
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Functional Studies - Recombinant human VEGF Receptor 3 protein (ab95247)The specific activity of ab95247 was found to be 17 pmol/min/µg by carrying out functional studies. The assay conditions were; VEGFR3 was incubated with a substrate (Tyr peptide 4) for 1h at RT in 1Xkinase buffer supplemented with ATP. Developer solution was added to reaction and reaction was stopped after 1h of incubation at RT.
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SDS-PAGE - Recombinant human VEGF Receptor 3 protein (ab95247)ab95247 was analysed by SDS-PAGE. Lane 1; ab95247 at 4µg. Lane 2; protein molecular weight markers. ab95247 has a predicted molecular weight of 82 kDa and is >70% pure as assessed by SDS-PAGE.
