Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant human TWEAKR/FN14 protein (ab50176)

Key features and details

  • Expression system: Escherichia coli
  • Endotoxin level:
  • Active: Yes
  • Suitable for: SDS-PAGE, Functional Studies

Description

  • Product name

    Recombinant human TWEAKR/FN14 protein
    See all TWEAKR/FN14 proteins and peptides

  • Biological activity

    Biological Activity : Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 µg/ml.

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

    • Molecular weight information

      5.6 kDa

    • Amino acids

      28 to 80

    • Specifications

    Our Abpromise guarantee covers the use of ab50176 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Functional Studies

    • Form

      Lyophilized

    • Additional notes

       This product was previously labelled as TWEAKR

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      Reconstitute to 1mg/ml in sterile water.

    General Info

    • Alternative names

      • CD 266
      • CD266
      • CD266 antigen
      • FGF inducible 14
      • FGF-inducible 14
      • Fibroblast growth factor inducible immediate early response protein 14
      • Fibroblast growth factor-inducible immediate-early response protein 14
      • FN 14
      • FN14
      • TNFRSF 12A
      • TNFRSF12A
      • TNR12_HUMAN
      • Tumor necrosis factor receptor superfamily member 12A
      • TWEAK R
      • Tweak receptor
      • Tweak-receptor
      • TweakR
      see all

    • Function

      Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

    • Tissue specificity

      Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

    • Sequence similarities

      Contains 1 TNFR-Cys repeat.

    • Cellular localization

      Membrane.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab50176? Please let us know so that we can cite the reference in this datasheet.

ab50176 has not yet been referenced specifically in any publications.

Preparation and Storage

  • CD 266
  • CD266
  • CD266 antigen

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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