Recombinant human TGF beta 3 protein (Animal Free) (ab217402)
Key features and details
- Expression system: Escherichia coli
- Purity: > 98% SDS-PAGE
- Active: Yes
- Suitable for: Functional Studies, SDS-PAGE, HPLC
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Product name
Recombinant human TGF beta 3 protein (Animal Free)
See all TGF beta 3 proteins and peptides -
Biological activity
Determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/mL, corresponding to a specific activity of ≥ 2 x 107 units/mg.
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Purity
> 98 % SDS-PAGE.
> 98 % HPLC. -
Expression system
Escherichia coli -
Accession
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Protein length
Full length protein -
Animal free
Yes -
Nature
Recombinant -
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Species
Human -
Sequence
ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPY LRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQ LSNMVVKSCKCS -
Predicted molecular weight
25 kDa -
Amino acids
301 to 412 -
Additional sequence information
Recombinant Human TGF-β3 is composed of two identical 12.7 kDa, 112 amino acid polypeptide chains linked by a single disulfide bond.
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Preparation and Storage
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Alternative names
- ARVD
- ARVD1
- FLJ16571
see all -
Function
Involved in embryogenesis and cell differentiation. -
Involvement in disease
Defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1) [MIM:107970]; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. -
Sequence similarities
Belongs to the TGF-beta family. -
Cellular localization
Secreted. - Information by UniProt
