Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human Semaphorin 3A protein (ab185410)

Key features and details

  • Expression system: Mammalian
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag C-Terminus
  • Suitable for: HPLC, SDS-PAGE

Description

  • Product name

    Recombinant Human Semaphorin 3A protein
    See all Semaphorin 3A proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

  • Endotoxin level

  • Expression system

    Mammalian

  • Accession

    Q14563

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      NYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLY VGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSP YDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRW LNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICK NDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPK NPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQ GRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWY DLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIY GKACAECCLARDPYCAWDGSACSRYFPTAKRATRAQDIRNGDPLTHCSDL HHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEE IRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVIDT EHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDE FCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRS VHHHHHH

    • Predicted molecular weight

      87 kDa including tags

    • Amino acids

      21 to 771

    • Tags

      His tag C-Terminus

    • Specifications

    Our Abpromise guarantee covers the use of ab185410 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      HPLC

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle.

      pH: 7.40
      Constituent: 100% PBS

    General Info

    • Alternative names

      • Coll 1
      • Coll1
      • Collapsin 1
      • HH16
      • Hsema I
      • Hsema III
      • Sema domain immunoglobulin domain (Ig) short basic domain secreted (semaphorin) 3A
      • sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
      • Sema III
      • SEMA1
      • SEMA1-PEN
      • SEMA3A
      • SEMAD
      • SEMAIII
      • SEMAL
      • Semaphorin 3A precursor
      • Semaphorin III
      • semaphorin L
      • Semaphorin like growth cone guidance homolog of chick collapsin
      • Semaphorin-D
      • Semaphorin3A
      • SemD
      see all

    • Relevance

      One family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPI anchored extracellular molecules that are involved in regulating axon guidance by inhibiting axons from growing toward incorrect targets. Semaphorin 3A (Sema3A) may play a particularly interesting role in limiting axon regeneration since it is expressed in meningeal fibroblasts that invade the injured spinal cord and surround the glial scar. In addition, the Sema3A co receptors, Neuropilin 1 and Plexin A1, are expressed on axons that regenerate up to the injured region, but do not cross this Sema3A containing region. Thus, Sema3A and its co receptors may have important roles in regulating axon guidance during neuronal development and after neuronal injury.

    • Cellular localization

      Secreted

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab185410? Please let us know so that we can cite the reference in this datasheet.

ab185410 has not yet been referenced specifically in any publications.

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituent: 100% PBS

Images

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