Recombinant Human PD-L1 (mutated K124A) protein (Tagged) (Biotin) (ab271697)
Key features and details
- Expression system: HEK 293 cells
- Purity: >= 90% SDS-PAGE
- Tags: Avi tag C-Terminus, Fc tag C-Terminus
- Suitable for: SDS-PAGE
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Product name
Recombinant Human PD-L1 (mutated K124A) protein (Tagged) (Biotin)
See all PD-L1 proteins and peptides -
Purity
>= 90 % SDS-PAGE. -
Expression system
HEK 293 cells -
Accession
-
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Predicted molecular weight
54 kDa including tags -
Amino acids
19 to 239 -
Modifications
biotinylated , mutated K124A -
Tags
Avi tag C-Terminus , Fc tag C-Terminus -
Additional sequence information
Human IgG1 Fc
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Conjugation
Biotin
Preparation and Storage
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Alternative names
- B7 H
- B7 H1
- B7 homolog 1
see all -
Function
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. -
Tissue specificity
Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. -
Sequence similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Cellular localization
Cell membrane and Endomembrane system. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human PD-L1 (mutated K124A) protein (Tagged) (Biotin) (ab271697)SDS-PAGE analysis of ab271697.
