Recombinant human PBK/SPK protein (ab70619)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Active: Yes
- Suitable for: SDS-PAGE
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Product name
Recombinant human PBK/SPK protein
See all PBK/SPK proteins and peptides -
Biological activity
ab70619 is inactive. -
Expression system
Baculovirus infected Sf9 cells -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human
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Preparation and Storage
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Alternative names
- Cancer/testis antigen 84
- CT84
- Epididymis luminal protein 164
see all -
Function
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. -
Tissue specificity
Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. -
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Contains 1 protein kinase domain. -
Post-translational
modificationsPhosphorylated; in a cell-cycle dependent manner at mitosis. - Information by UniProt
Images
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SDS-PAGE - Recombinant human PBK/SPK protein (ab70619)SDS-PAGE showing ab70619 at approximately 68kDa.
