T0901317, LXR agonist (ab142808)
Key features and details
- Potent, non-selective LXR agonist
- CAS Number: 293754-55-9
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
T0901317, LXR agonist -
Description
Potent, non-selective LXR agonist -
Biological description
Potent, non-selective LXR agonist (EC50 = 50 nM). Increases ABCA1 expression associated with cholesterol efflux regulation and HDL metabolism. Increases muscle expression of PPAR-δ. Shows antiobesogenic effects in vivo.
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Purity
> 99% -
CAS Number
293754-55-9 -
Chemical structure
Properties
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Chemical name
N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide -
Molecular weight
481.33 -
Molecular formula
C17H12F9NO3S -
PubChem identifier
447912 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=S(=O)(N(CC(F)(F)F)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c2ccccc2 -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
