Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant human Myostatin Propeptide protein (ab49855)

Key features and details

  • Expression system: Escherichia coli
  • Endotoxin level:
  • Active: Yes
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant human Myostatin Propeptide protein
    See all Myostatin Propeptide proteins and peptides

  • Biological activity

    Determined by its ability to neutralize the Myostatin inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.01–0.04 μg/ml in the presence of 50 ng/ml Myostatin.

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Accession

    O14793

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MNENSEQKEN VEKEGLCNAC TWRQNTKSSR IEAIKIQILS KLRLETAPNI SKDVIRQLLP KAPPLRELID QYDVQRDDSS DGSLEDDDYH ATTETIITMP TESDFLMQVD GKPKCCFFKF SSKIQYNKVV KAQLWIYLRP VETPTTVFVQ ILRLIKPMKD GTRYTGIRSL KLDMNPGTGI WQSIDVKTVL QNWLKQPESN LGIEIKALDE NGHDLAVTFP GPGEDGLNPF LEVKVTDTPK RSRR

    • Predicted molecular weight

      28 kDa

    • Amino acids

      23 to 266

    • Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab49855 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        SDS-PAGE

      • Form

        Lyophilized
      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

        This product is an active protein and may elicit a biological response in vivo, handle with caution.

      • Reconstitution
        For lot specific reconstitution information please contact our Scientific Support Team.

      General Info

      • Alternative names

        • Cmpt
        • GDF-8
        • GDF8_HUMAN
        • Growth/differentiation factor 8
        • MSLHP
        • MSTN
        • MSTN myostatin
        • Myostatin
        • Myostatin Propeptide
        see all

      • Function

        Acts specifically as a negative regulator of skeletal muscle growth.

      • Involvement in disease

        Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong.

      • Sequence similarities

        Belongs to the TGF-beta family.

      • Cellular localization

        Secreted.
      • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab49855? Please let us know so that we can cite the reference in this datasheet.

    ab49855 has not yet been referenced specifically in any publications.

    Preparation and Storage

    • Alternative names

      • Cmpt
      • GDF-8
      • GDF8_HUMAN
      • Growth/differentiation factor 8
      • MSLHP
      • MSTN
      • MSTN myostatin
      • Myostatin
      • Myostatin Propeptide
      see all

    • Function

      Acts specifically as a negative regulator of skeletal muscle growth.

    • Involvement in disease

      Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong.

    • Sequence similarities

      Belongs to the TGF-beta family.

    • Cellular localization

      Secreted.
    • Information by UniProt

    Images

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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