• Product name

  Recombinant human Melanoma Inhibitory Activity protein
  See all Melanoma Inhibitory Activity proteins and peptides

• Biological activity

  The ED₅₀ was determined by the dose-dependant proliferation of the human A375 melanoma cell line. The expected ED₅₀ for this effect is 4-6 μg/ml.

• Purity

  > 95 % SDS-PAGE.
  Greater than 98% by SDS-PAGE and HPLC analyses.
  

• Expression system

  Escherichia coli

• Protein length

  Protein fragment

• Animal free

  No

• Nature

  Recombinant

• • Species

    Human

  • Sequence

    MGPMPKLADR KLCADQECSH PISMAVALQD YMAPDCRFLT IHRGQVVYVF SKLKGRGRLF WGGSVQGDYY GDLAARLGYF PSSIVREDQT LKPGKVDVKT DKWDFYCQ

• Alternative names

  • Cartilage derived retinoic acid sensitive protein
  • CD RAP
  • CDRAP

  • Melanoma derived growth regulatory protein precursor
  • Melanoma inhibitory activity protein
  • Melanoma-derived growth regulatory protein
  • Mia
  • MIA_HUMAN

  see all

• Function

  Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

• Tissue specificity

  All malignant melanoma cell lines tested and infrequently in glioma cell lines.

• Sequence similarities

  Belongs to the MIA/OTOR family.
  Contains 1 SH3 domain.

• Post-translational
  modifications

  May possess two intramolecular disulfide bonds.

• Cellular localization

  Secreted.

• Target information above from: UniProt accession Q16674 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt