Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human ILT-4 protein (ab151846)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag C-Terminus
  • Suitable for: SDS-PAGE, HPLC

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C.

    pH: 7.20
    Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

  • Reconstitution
    Lyophilized from a 0.2 µM filtered solution. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100 µg/ml.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at

    General Info

    • Alternative names

      • CD85 antigen-like family member D
      • CD85d
      • CD85d antigen
      • ILT 4
      • ILT-4
      • ILT4
      • Immunoglobulin like transcript 4
      • Immunoglobulin-like transcript 4
      • Leukocyte immunoglobulin like receptor 2
      • Leukocyte immunoglobulin like receptor subfamily B member 2
      • Leukocyte immunoglobulin-like receptor 2
      • Leukocyte immunoglobulin-like receptor subfamily B member 2
      • Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
      • LILRA6
      • LILRB2
      • LIR 2
      • LIR-2
      • LIR2
      • LIRb
      • LIRB2_HUMAN
      • MIR 10
      • MIR-10
      • MIR10
      • Monocyte/macrophage immunoglobulin like receptor 10
      • Monocyte/macrophage immunoglobulin-like receptor 10
      see all

    • Function

      Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

    • Tissue specificity

      Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.

    • Sequence similarities

      Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

    • Domain

      Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

    • Post-translational
      modifications

      Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.

    • Cellular localization

      Membrane.
    • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

References (0)

Publishing research using ab151846? Please let us know so that we can cite the reference in this datasheet.

ab151846 has not yet been referenced specifically in any publications.

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