Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant human IL-17A protein (Fc Chimera) (ab214605)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: >= 98% SDS-PAGE
  • Endotoxin level:
  • Active: Yes
  • Suitable for: SDS-PAGE, Functional Studies

Description

  • Product name

    Recombinant human IL-17A protein (Fc Chimera)
    See all IL-17A proteins and peptides

  • Biological activity

    Measured by its ability to induce IL-6 secretion.

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    HEK 293 cells

  • Accession

    Q16552

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      IVKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA

    • Predicted molecular weight

      16 kDa

    • Amino acids

      20 to 155

    • Additional sequence information

      This product is for the mature full length protein. The signal peptide is not included. Fused to the N-terminus of the Fc region of mutant human IgG1.

    • Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab214605 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        SDS-PAGE

        Functional Studies

      • Form

        Lyophilized

      • Additional notes

        Non-lytic

      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

        Constituent: 100% PBS

        This product is an active protein and may elicit a biological response in vivo, handle with caution.

      • Reconstitution
        Reconstitute with 50 µl sterile water to a concentration of 1mg/ml. Add 1X PBS to the desired protein concentration.

      General Info

      • Alternative names

        • CTLA 8
        • CTLA-8
        • CTLA8
        • cytotoxic T lymphocyte associated antigen 8
        • Cytotoxic T lymphocyte associated protein 8
        • Cytotoxic T lymphocyte associated serine esterase 8
        • Cytotoxic T-lymphocyte-associated antigen 8
        • IL 17
        • IL 17A
        • IL-17
        • IL-17A
        • IL17
        • IL17_HUMAN
        • Il17a
        • Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8)
        • interleukin 17A
        • Interleukin-17A
        • interleukin17
        • Interleukin17A
        • OTTHUMP00000016597
        • OTTMUSP00000046003
        see all

      • Function

        Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.

      • Tissue specificity

        Restricted to activated memory T-cells.

      • Sequence similarities

        Belongs to the IL-17 family.

      • Post-translational
        modifications

        Found both in glycosylated and nonglycosylated forms.

      • Cellular localization

        Secreted.
      • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab214605? Please let us know so that we can cite the reference in this datasheet.

    ab214605 has not yet been referenced specifically in any publications.

    Preparation and Storage

    • Alternative names

      • CTLA 8
      • CTLA-8
      • CTLA8
      • cytotoxic T lymphocyte associated antigen 8
      • Cytotoxic T lymphocyte associated protein 8
      • Cytotoxic T lymphocyte associated serine esterase 8
      • Cytotoxic T-lymphocyte-associated antigen 8
      • IL 17
      • IL 17A
      • IL-17
      • IL-17A
      • IL17
      • IL17_HUMAN
      • Il17a
      • Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8)
      • interleukin 17A
      • Interleukin-17A
      • interleukin17
      • Interleukin17A
      • OTTHUMP00000016597
      • OTTMUSP00000046003
      see all

    • Function

      Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.

    • Tissue specificity

      Restricted to activated memory T-cells.

    • Sequence similarities

      Belongs to the IL-17 family.

    • Post-translational
      modifications

      Found both in glycosylated and nonglycosylated forms.

    • Cellular localization

      Secreted.
    • Information by UniProt

    Images

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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