Recombinant human IgG2 protein (ab182668)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Suitable for: SDS-PAGE
Preparation and Storage
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Alternative names
- Ig gamma-2 chain C region
- IGHG2
- immunoglobulin Gm2
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Relevance
There are four IgG subclasses (IgG1, 2, 3 and 4) in humans, named in order of their abundance in serum (IgG1 being the most abundant). IgG2 is the only IgG subclass which passes through the placenta at a level generally lower than that found in the mother. A deficiency of IgG2 indicates a poor antibody response to bacterial polysaccharides and can lead to increased susceptibility to infections caused by encapsulated bacteria. -
Cellular localization
Secreted
Images
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SDS-PAGE - Recombinant human IgG2 protein (ab182668)
Human IgG Fc (Tag Free) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The protein migrates as 33-35 kDa due to glycosylation.
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Surface Plasmon Resonance - Recombinant human IgG2 protein (ab182668)Human FCGRT & B2M Heterodimer Protein, His Tag (SPR & BLI verified) captured on CM5 Chip via anti-His antibody can bind ab182668 with an affinity constant of 33.3 nM as determined in SPR assay (Biacore 8K).
