• Product name

  Recombinant mouse FGF1 protein
  See all FGF1 proteins and peptides

• Biological activity

  Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED₅₀ is ≤ 0.2 ng/ml in the presence of 10 µg/ml heparin, corresponding to a specific activity of ≥ 5 x 10⁶ units/mg.

• Purity

  > 95 % SDS-PAGE.
  Purity greater than 95% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  

• Expression system

  Escherichia coli

• Protein length

  Full length protein

• Animal free

  No

• Nature

  Recombinant

• • Species

    Mouse

  • Sequence

    MFNLPLGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SAGEVYIKGT ETGQYLAMDT EGLLYGSQTP NEECLFLERL EENHYNTYTS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D

• Alternative names

  • Acidic fibroblast growth factor
  • aFGF
  • Beta endothelial cell growth factor

  • Beta-endothelial cell growth factor
  • ECGF
  • ECGF beta
  • ECGF-beta
  • ECGFA
  • ECGFB
  • Endothelial Cell Growth Factor alpha
  • Endothelial Cell Growth Factor beta
  • FGF 1
  • FGF alpha
  • Fgf1
  • FGF1_HUMAN
  • FGFA
  • Fibroblast growth factor 1
  • Fibroblast Growth Factor 1 Acidic
  • GLIO703
  • HBGF 1
  • HBGF-1
  • HBGF1
  • Heparin binding growth factor 1
  • Heparin binding growth factor 1 precursor
  • Heparin-binding growth factor 1

  see all

• Function

  The heparin-binding fibroblast growth factors play important roles in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. They are potent mitogens in vitro.

• Sequence similarities

  Belongs to the heparin-binding growth factors family.

• Cellular localization

  Secreted. Cytoplasm. Cytoplasm > cell cortex. Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1.

• Target information above from: UniProt accession P05230 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt