Recombinant Human HRG beta 1 protein (ab55742)
Key features and details
- Expression system: Escherichia coli
- Purity: > 98% SDS-PAGE
- Suitable for: SDS-PAGE, Functional Studies
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Product name
Recombinant Human HRG beta 1 protein
See all HRG beta 1 proteins and peptides -
Purity
> 98 % SDS-PAGE.
purification checked by SDS Page and HPLC. -
Expression system
Escherichia coli -
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQ NYVM ASFYKHLGIE FMEAE
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Preparation and Storage
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Alternative names
- Acetylcholine receptor inducing activity
- ARIA
- Breast cancer cell differentiation factor p45
see all -
Relevance
HRG beta 1 is an isoform from the Neuregulin/Heregulin family of structurally related polypeptide growth factors which are derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. HRG1-ß1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. Although HRG1-ß1 biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility promoting factor (AMF). -
Cellular localization
Secreted
