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Recombinant Human GITR protein (Fc Chimera) (ab198670)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 90% SDS-PAGE
  • Endotoxin level:
  • Suitable for: SDS-PAGE

Preparation and Storage

  • Alternative names

    • Activation inducible TNFR family receptor
    • Activation-inducible TNFR family receptor
    • AITR
    • CD357
    • GITR
    • GITR D
    • GITR-D
    • GITRD
    • Glucocorticoid induced TNFR related protein
    • glucocorticoid-induced tnf receptor ligand
    • glucocorticoid-induced tnf receptors ligand
    • Glucocorticoid-induced TNFR-related protein
    • TNF receptor superfamily activation inducible protein
    • TNFRSF 18
    • TNFRSF18
    • TNR18_HUMAN
    • Tumor necrosis factor receptor superfamily member 18
    • Tumor necrosis factor receptor superfamily member 18 precursor
    see all

  • Function

    Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

  • Tissue specificity

    Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

  • Sequence similarities

    Contains 3 TNFR-Cys repeats.

  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human GITR protein (Fc Chimera) (ab198670)
    SDS-PAGE - Recombinant Human GITR protein (Fc Chimera) (ab198670)

    4-20% SDS-PAGE analysis of ab198670 (3 μg) with Coomassie staining.

    Note: This protein runs at a higher MW by SDS-PAGE due to glycosylation.

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