Antibodies, Proteins, Kits and Reagents for Life Science

Recombinant Human GITR protein (Fc Chimera) (ab198670)

Key features and details

Expression system: HEK 293 cells
Purity: > 90% SDS-PAGE
Endotoxin level:
Suitable for: SDS-PAGE

Alternative names
- Activation inducible TNFR family receptor
- Activation-inducible TNFR family receptor
- AITR
- CD357
- GITR
- GITR D
- GITR-D
- GITRD
- Glucocorticoid induced TNFR related protein
- glucocorticoid-induced tnf receptor ligand
- glucocorticoid-induced tnf receptors ligand
- Glucocorticoid-induced TNFR-related protein
- TNF receptor superfamily activation inducible protein
- TNFRSF 18
- TNFRSF18
- TNR18_HUMAN
- Tumor necrosis factor receptor superfamily member 18
- Tumor necrosis factor receptor superfamily member 18 precursor
see all
Function

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Tissue specificity

Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
Sequence similarities

Contains 3 TNFR-Cys repeats.
Cellular localization

Secreted and Cell membrane.
Target information above from: UniProt accession Q9Y5U5 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human GITR protein (Fc Chimera) (ab198670)

4-20% SDS-PAGE analysis of ab198670 (3 μg) with Coomassie staining.
Note: This protein runs at a higher MW by SDS-PAGE due to glycosylation.

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