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Recombinant Human FGFR4 protein (Fc Chimera) (ab83999)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 95% SDS-PAGE
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Human FGFR4 protein (Fc Chimera)
    See all FGFR4 proteins and peptides

  • Purity

    > 95 % SDS-PAGE.

  • Expression system

    HEK 293 cells

  • Accession

    P22455

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      Theoretical Sequence: LEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA ERGGHWYKEGSRLAPAGRVR GWRGRLEIASFLPEDAGRYLCLARGSMI VLQNLTLITGDSLTSSNDDEDPKSHRDLSNRHS YPQQAPYWTHPQRME KKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIR IPK VDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTV LHQDWLNGKEYKCRVSNKAL PAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLTCLVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSF FLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

    • Amino acids

      22 to 201

    • Additional sequence information

      Encodes the signal peptide and extracellular domain of human FGF R4 (aa1-201) was fused to the Fc region of human IgG1 (aa 93-330). The chimeric protein was expressed in modified human 293 cells.

Preparation and Storage

  • Alternative names

    • CD 334
    • CD334
    • CD334 antigen
    • fc13h 10
    • fc13h10
    • Fgfr 4
    • FGFR-4
    • Fgfr4
    • FGFR4_HUMAN
    • Fibroblast growth factor receptor 4
    • Hydroxyaryl protein kinase
    • JTK 2
    • JTK2
    • MGC20292
    • Protein tyrosine kinase
    • TKF
    • Tyrosine kinase related to fibroblast growth factor receptor
    • Tyrosylprotein kinase
    see all

  • Function

    Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.

  • Tissue specificity

    Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.

  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.

  • Post-translational
    modifications

    Glycosylated.
    Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization.

  • Cellular localization

    Membrane. Isoform 2 may be secreted.
  • Information by UniProt

Images

  • Functional Studies - Recombinant Human FGFR4 protein (Fc Chimera) (ab83999)
    Functional Studies - Recombinant Human FGFR4 protein (Fc Chimera) (ab83999)
    Densitometry of protein isoforms visualised by 2-DE.
    The densitometry scan demonstrates the purified human cell expressed protein exists in multiple isoforms, which differ according to their level of post-translational modification.
    The triangle indicates the theoretical MW and pI of the protein.

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