Tiagabine hydrochloride, GAT-1 inhibitor (ab120237)
Key features and details
- Selective GAT-1 inhibitor
- CAS Number: 115103-54-3
- Purity: > 99%
- Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Tiagabine hydrochloride, GAT-1 inhibitor -
Description
Selective GAT-1 inhibitor -
Alternative names
- Gabitril
- NNC 05-328
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Biological description
GABA uptake inhibitor, selective for GAT-1. Anticonvulsant in vivo.
Also available in simple stock solutions (ab146701) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 99% -
CAS Number
115103-54-3 -
Chemical structure
Properties
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Chemical name
(3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid hydrochloride -
Molecular weight
412.00 -
Molecular formula
C20H25NO2S2.HCl -
PubChem identifier
91274 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cc3ccsc3C(=CCCN1CCC[C@H](C1)C(=O)O)c2sccc2C -
Source
Synthetic
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Research areas
Images
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Functional Studies - Tiagabine hydrochloride, GAT-1 inhibitor (ab120237) Rideau Batista Novais et al PLoS One. 2014 Sep 3;9(9):e106302. doi: 10.1371/journal.pone.0106302. eCollection 2014. Fig 4. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
Tiagabine restored LTD via the activation of GABAB receptors in LPS animals.
Tiagabine (20 µM) and/or CGP55845 (1 µM) were applied in the perfusate during both the recording of baseline activity and LFS (1 Hz stimulation, 15 min) delivery. (Panel A) Time-course and recapitulative graph depicting LTD induction in control (SAL) animals. LFS induced an LTD of fEPSP amplitude in control animals (SAL; filled circles; N = 8), which was significantly blocked by the GABAB receptor antagonist CGP55845 (SAL+CGP; open circles; N = 5; * p