Antibodies, Proteins, Kits and Reagents for Life Science

Recombinant Human CD62L protein (Fc Chimera) (ab83824)

Key features and details

Expression system: HEK 293 cells
Purity: > 95% SDS-PAGE
Suitable for: SDS-PAGE

Product name

Recombinant Human CD62L protein (Fc Chimera)
See all CD62L proteins and peptides
Purity

> 95 % SDS-PAGE.
Expression system

HEK 293 cells
Accession

P14151
Protein length

Protein fragment
Animal free

No
Nature

Recombinant
- Species
  
  Human
- Sequence
  
  Theoretical Sequence: WTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSY YWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRN KDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGY YGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGI EETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACT FICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDWIPKVD KKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCV VVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCRVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- Amino acids
  
  1 to 343
- Additional sequence information
  
  Fused with the Fc region of Human IgG1 at the C-terminus.

Alternative names
- A.11
- AI528707
- CD62 antigen ligand
- CD62 antigen-like family member L
- CD62L
- gp90-MEL
- IgA nephropathy, susceptibility to, included
- L Selectin
- L-selectin
- LAM-1
- LAM1
- LECAM1
- LEU8
- Leukocyte adhesion molecule 1
- Leukocyte surface antigen Leu-8
- Leukocyte-endothelial cell adhesion molecule 1
- Lnhr
- LSEL
- Ly-22
- Ly-m22
- Lyam-1
- LYAM1
- LYAM1_HUMAN
- Lymph node homing receptor
- Lymphocyte adhesion molecule 1
- Lymphocyte antigen 22
- Lymphocyte surface MEL-14 antigen
- MEL-14
- Pln homing receptor
- PLNHR
- Selectin L
- Selectin, lymphocyte
- SELL
- TQ1
see all
Function

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
Tissue specificity

Expressed in B cell lines and T lymphocytes.
Sequence similarities

Belongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 2 Sushi (CCP/SCR) domains.
Cellular localization

Membrane.
Target information above from: UniProt accession P14151 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

Functional Studies - Recombinant Human CD62L protein (Fc Chimera) (ab83824)

Densitometry of protein isoforms visualised by 2-DE.
The densitometry scan demonstrates the purified Human cell expressed protein exists in multiple isoforms, which differ according to their level of post-translational modification.
The triangle indicates the theoretical MW and pI of the protein.
SDS-PAGE - Recombinant Human CD62L protein (Fc Chimera) (ab83824)

1D SDS-PAGE of ab83824 before and after treatment with glycosidases to remove oligosaccharides.
Lane 1: ab83824
Lane 2: ab83824 treated with PNGase F to remove potential N-linked glycans
10 μg protein loaded per lane; Deep Purple™ stained.
Drop in MW after treatment with PNGase F indicates presence of N-linked glycans.

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