Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human BDNF protein (ab151895)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Suitable for: HPLC, SDS-PAGE

Description

  • Product name

    Recombinant Human BDNF protein
    See all BDNF proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    ab151895 is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Lyophilized from a 0.2 µM filtered solution.

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Accession

    P23560

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQL KQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIG WRFIRIDTSCVCTLTIKRGR

    • Predicted molecular weight

      27 kDa

    • Amino acids

      129 to 247

    • Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab151895 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        HPLC

        SDS-PAGE

      • Form

        Lyophilized
      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at 4°C. Store at -80°C.

        pH: 7.20
        Constituents: 98% Phosphate Buffer, 1.46% Sodium chloride

      • Reconstitution
        Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

      General Info

      • Alternative names

        • Abrineurin
        • ANON2
        • BDNF
        • BDNF_HUMAN
        • Brain Derived Neurotrophic Factor
        • Brain-derived neurotrophic factor
        • BULN2
        • MGC34632
        • Neurotrophin
        see all

      • Function

        During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

      • Tissue specificity

        Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.

      • Involvement in disease

        Bulimia nervosa 2
        Congenital central hypoventilation syndrome

      • Sequence similarities

        Belongs to the NGF-beta family.

      • Post-translational
        modifications

        The propeptide is N-glycosylated and glycosulfated.
        Converted into mature BDNF by plasmin (PLG).

      • Cellular localization

        Secreted.
      • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab151895? Please let us know so that we can cite the reference in this datasheet.

    ab151895 has not yet been referenced specifically in any publications.

    Preparation and Storage

    • Alternative names

      • Abrineurin
      • ANON2
      • BDNF
      • BDNF_HUMAN
      • Brain Derived Neurotrophic Factor
      • Brain-derived neurotrophic factor
      • BULN2
      • MGC34632
      • Neurotrophin
      see all

    • Function

      During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

    • Tissue specificity

      Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.

    • Involvement in disease

      Bulimia nervosa 2
      Congenital central hypoventilation syndrome

    • Sequence similarities

      Belongs to the NGF-beta family.

    • Post-translational
      modifications

      The propeptide is N-glycosylated and glycosulfated.
      Converted into mature BDNF by plasmin (PLG).

    • Cellular localization

      Secreted.
    • Information by UniProt

    Images

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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