Recombinant human BDNF protein (ab206642)
Key features and details
- Expression system: Escherichia coli
- Endotoxin level:
- Active: Yes
- Suitable for: HPLC, SDS-PAGE, Functional Studies
Preparation and Storage
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Alternative names
- Abrineurin
- ANON2
- BDNF
see all -
Function
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. -
Tissue specificity
Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta. -
Involvement in disease
Bulimia nervosa 2
Congenital central hypoventilation syndrome -
Sequence similarities
Belongs to the NGF-beta family. -
Post-translational
modificationsThe propeptide is N-glycosylated and glycosulfated.
Converted into mature BDNF by plasmin (PLG). -
Cellular localization
Secreted. - Information by UniProt
Images
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Functional Studies - Recombinant human BDNF protein (ab206642)Functional analysis of ab206642
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SDS-PAGE - Recombinant human BDNF protein (ab206642)SDS PAGE analysis of ab206642 under non-reducing (-) and reducing (+) conditions. Stained with Coomassie Blue.
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Functional Studies - Recombinant human BDNF protein (ab206642)C6 cells were cultured with 0 to 10 ug/mL Human BDNF. Cell proliferation was measured after 7 days and the linear portion of the curve was used to calculate the ED50.
The ED50 of this lot of ab206642 is 0.5-0.8 ug/mL.
This value is comparable to the expected range of 0.5-1.5 ug/mL.
