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Recombinant human BCMA protein (Active) (ab243796)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 98% SDS-PAGE
  • Endotoxin level:
  • Active: Yes
  • Suitable for: Functional Studies, HPLC, SDS-PAGE

Preparation and Storage

  • Alternative names

    • B cell maturation antigen
    • B cell maturation factor
    • B cell maturation protein
    • B-cell maturation protein
    • BCM
    • BCMA
    • CD269
    • CD269 antigen
    • TNFRSF17
    • TNR17_HUMAN
    • Tumor necrosis factor receptor superfamily member 17
    see all

  • Function

    Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

  • Tissue specificity

    Expressed in mature B-cells, but not in T-cells or monocytes.

  • Involvement in disease

    Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

  • Sequence similarities

    Contains 1 TNFR-Cys repeat.

  • Cellular localization

    Cell membrane. Endomembrane system. Perinuclear Golgi-like structures.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant human BCMA protein (Active) (ab243796)
    SDS-PAGE - Recombinant human BCMA protein (Active) (ab243796)
    SDS-PAGE analysis of ab243796

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