QNZ, NF-kB inhibitor (ab141588)
Key features and details
- Potent, selective NF-kB inhibitor
- CAS Number: 545380-34-5
- Purity: > 98%
- Soluble in DMSO to 50 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
QNZ, NF-kB inhibitor -
Description
Potent, selective NF-kB inhibitor -
Biological description
Potent, selective NF-kB inhibitor (IC50 = 11 nM). Inhibits LPS-induced TNFα production (IC50 = 7 nM). Reduces edema in inflammation in vivo. -
Purity
> 98% -
CAS Number
545380-34-5 -
Chemical structure
Properties
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Chemical name
4-N-[2-(4-Phenoxyphenyl)ethyl]-1,2-dihydroquinazoline-4,6-diamine -
Molecular weight
356.40 -
Molecular formula
C22H20N4O -
PubChem identifier
35026803 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1NC2=C(C=C(C=C2)N)C(=N1)NCCC3=CC=C(C=C3)OC4=CC=CC=C4 -
Source
Synthetic
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Research areas