PIT-1, PIP3/protein binding inhibitor (ab120885)
Key features and details
- PIP3/protein binding inhibitor
- CAS Number: 53501-41-0
- Purity: > 98%
- Soluble in DMSO to 20 mg/ml and in ethanol to 0.5 mg/ml
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PIT-1, PIP3/protein binding inhibitor -
Description
PIP3/protein binding inhibitor -
Biological description
PIP3/protein binding inhibitor. Specifically disrupts PIP3/Akt PH domain binding (IC50 = 31 μM); suppresses PI3K-PDK1-Akt-dependent phosphorylation. Reduces cell viability and induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM). 3,5-Dimethyl PIT-1 (ab120884) also available. -
Purity
> 98% -
CAS Number
53501-41-0 -
Chemical structure
Properties
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Chemical name
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide -
Molecular weight
351.76 -
Molecular formula
C14H10ClN3O4S -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 20 mg/ml and in ethanol to 0.5 mg/ml -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(NC(NC1=C(O)C(Cl)=CC([N+]([O-])=O)=C1)=S)C2=CC=CC=C2 -
Source
Synthetic
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Research areas
