Ponesimod, sphingosine-1-phophate receptor agonist (ab231509)
Key features and details
- Potent sphingosine-1-phophate receptor agonist
- CAS Number: 854107-55-4
Soluble in DMSO to 10 mM.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ponesimod, sphingosine-1-phophate receptor agonist -
Description
Potent sphingosine-1-phophate receptor agonist -
Biological description
Ponesimod is a potent agonist of sphingosine-1-phophate receptor. (S1P1/EDG-1; IC50s = 6, >10,000, 2,068, 1,956, and 142 nM for S1P1-S1P5, respectively, in a radioligand binding assay). Selectively activates S1P1 in a GTPγS assay (EC50s = 5.7, >10,000, 105, 1,108, and 59.1 nM, for S1P1-S1P5, respectively).
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CAS Number
854107-55-4 -
Chemical structure
Properties
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Chemical name
(5Z)-5-[[3-Chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-one
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Molecular weight
460.97 -
Molecular formula
C23H25ClN2O4S -
PubChem identifier
11363176 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Solubility overview
Soluble in DMSO to 10 mM.
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SMILES
CCCN=C1N(C(=O)/C(=C/C2=CC(=C(C=C2)OC[C@@H](CO)O)Cl)/S1)C3=CC=CC=C3C -
Source
Synthetic
